Briefly describe the genes involved and their functions in translocations that result in non – fusion genes / non – fusion proteins in leukemia
Non-Fusion Genes in Leukemia Translocations: A Brief Overview While many leukemia-associated translocations result in fusion genes and subsequently, chimeric proteins with altered functions, some translocations disrupt genes without creating fusion products. These disruptions can still contribute to leukemia development through various mechanisms. Let’s explore some examples: 1. Deregulation of Gene Expression: 2. Gene Disruption/Loss of Function: Examples of genes commonly affected by these mechanisms: It’s important to note that the specific consequences of a translocation depend on various factors, including the genes involved, the location of breakpoints, and the resulting changes in gene expression or function.